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Träfflista för sökning "WFRF:(Förlin Lars 1950 ) ;mspu:(article);pers:(Förlin Lars 1950);lar1:(gu);pers:(Norrgren L)"

Search: WFRF:(Förlin Lars 1950 ) > Journal article > Förlin Lars 1950 > University of Gothenburg > Norrgren L

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  • Kling, Peter, 1968, et al. (author)
  • Gender-specific proteomic responses in zebrafish liver following exposure to a selected mixture of brominated flame retardants
  • 2008
  • In: Ecotoxicology and Environmental Safety. - : Elsevier Inc. - 1090-2414 .- 0147-6513. ; 71:2, s. 319-27
  • Journal article (peer-reviewed)abstract
    • Proteomic effect screening in zebrafish liver was performed to generate hypotheses following exposure (21 days) to a structurally diverse mixture of brominated flame retardants (BFRs). Fish were exposed to two doses (10 and 100 nmol/g feed). Two-dimensional gel-electrophoresis, image analysis and MALDI-TOF mass-spectrometry revealed 13 and 19 significant responses in males and females, respectively. Effects on proteins related to cellular maintenance and stress were observed in both genders. Regulated proteins were gender-specific, but functionally indicated common protective responses (peroxiredoxin 6 and Zgc:92891 in males and transketolase in females) suggesting oxidative stress. Betaine homocysteine methyltransferase (BHMT) was induced in both genders. In addition a female-specific downregulation of ironhomeostatic proteins (iron-regulatory protein 1 and transferrin) were observed. Our proteomic approach revealed novel responses that suggest important gender-specific sensitivity to BFRs that should be considered when interpreting adverse effects of BFRs.
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  • Result 1-2 of 2
Type of publication
journal article  (2)Undo refine
Type of content
peer-reviewed (2)
Author/Editor
Förlin, Lars, 19... (2)Undo refine
Norrgren, L (2)Undo refine
Pettersson, H (1)
Norman, A (1)
Kling, Peter, 1968 (1)
Carney Almroth, Beth ... (1)
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Andersson, Patrik (1)
Börjeson, L (1)
Lundström, J (1)
Amcoff, A (1)
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University
University of Gothenburg  (2)Undo refine
Umeå University (1)
Language
English (2)
Research subject (UKÄ/SCB)
Natural sciences (2)

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